Permethrin is a substance that belongs to the class of pyrethroid insecticides, it acts as an insecticide and acaricide, and exerts a repellent action against sandflies, mosquitoes and ticks.

Monthly use of Frontline Tri-Act will help you protect your dog in areas at high risk of sandflies (transmitters of Leishmaniasis), mosquitoes (Heartworm), ticks (Babesiosis, Ehrlichiosis, Anaplasmosis, Lyme Disease) and fleas ( Rickettsial Fever, Dipilidiosis, Bartonellosis).

Frontline Tri-Act is effective against 3 groups of ectoparasites in dogs: fleas, ticks and flying insects (phlebotomines, mosquitoes and stable flies).

Insecticidal effectiveness against fleas:
- Against the two main species that infest dogs: Ctenocephalides felis and C. canis.
- 99% efficiency against fleas persistent for 4 weeks, even under water exposure (2 or 3 dips) and 1 shampoo bath.
- Persistent fast action on flea removal for 4 weeks. Fast-acting, >95% effective within the first hour, during the first week and greater than 99% effective within the first 6 hours, for 4 weeks.

Fights the main species of ticks:
- 4 weeks of protection against the 3 main species of ticks that infest dogs in Europe, including Dermacentor reticulatus, the vector of canine Babesiosis.
- Proven repellent efficacy against D. reticulatus.

It acts effectively as a repellent for the vectors of Leishmaniasis, Dirofilariasis and stable flies:
- Sandflies (Phlebotomus perniciosus): > 90% repellency for 3 weeks and > 80% for 5 weeks.
- Mosquitoes (Culex pipiens): ≥90.4% for 4 weeks.
- Stable flies (Stomoxys calcitrans): > 88.6% for 5 weeks.

Persistent insecticidal efficacy against:
- Phlebotomus for 3 weeks (Phlebotomus perniciosus).
- Stable flies for 5 weeks (Stomoxys calcitrans).

Treatment schedule:
As protection against fleas, ticks and flying insects: application every 4 weeks on the dog.

Application:
- To achieve maximum effectiveness with Frontline Tri-Act , it is important to apply the product correctly.
- The contents of the pipette must be applied directly to the dog's skin at two different points: at the base of the neck and in the area between the shoulder blades.
- You can bathe the animal up to two days before application. In order for the product to spread optimally, the dog's skin must be dry when the product is applied.

Step 1:   Hold the pipette upright and cut the tip with scissors.
Step 2:   part the fur at the base of the dog's neck.
Step 3:   Place the pipette directly on the skin and squeeze several times to apply about half of the product.
Step 4:   Repeat the same operation in the area between the shoulder blades until the pipette is completely empty.

The product was well tolerated in puppies and adults at a dose of up to 5 times the maximum recommended dose.

The product can be used on puppies from 8 weeks of age and weighing at least 2 kg.

Product safety in pregnant or lactating bitches
Laboratory animal studies with Fipronil or Permethrin did not reveal any teratogenic or embryotoxic effects. No studies have been performed with this veterinary medicinal product in pregnant or lactating bitches, therefore the product should only be used after a benefit-risk assessment under the recommendation of a veterinarian.